Curis (NASDAQ:CRIS – Get Free Report) and ImmunityBio (NASDAQ:IBRX – Get Free Report) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, institutional ownership, analyst recommendations, earnings, profitability, valuation and dividends.
Profitability
This table compares Curis and ImmunityBio’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Curis | -443.35% | -923.37% | -78.35% |
| ImmunityBio | -8,016.83% | N/A | -110.02% |
Valuation and Earnings
This table compares Curis and ImmunityBio”s gross revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Curis | $10.26 million | 1.20 | -$47.41 million | ($7.81) | -0.19 |
| ImmunityBio | $14.75 million | 171.33 | -$583.20 million | ($0.63) | -4.70 |
Volatility and Risk
Curis has a beta of 3.49, indicating that its stock price is 249% more volatile than the S&P 500. Comparatively, ImmunityBio has a beta of 0.82, indicating that its stock price is 18% less volatile than the S&P 500.
Insider and Institutional Ownership
30.0% of Curis shares are owned by institutional investors. Comparatively, 8.6% of ImmunityBio shares are owned by institutional investors. 5.7% of Curis shares are owned by company insiders. Comparatively, 83.4% of ImmunityBio shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.
Analyst Recommendations
This is a summary of current ratings and target prices for Curis and ImmunityBio, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Curis | 0 | 0 | 3 | 0 | 3.00 |
| ImmunityBio | 0 | 1 | 3 | 1 | 3.00 |
Curis currently has a consensus target price of $21.00, suggesting a potential upside of 1,338.36%. ImmunityBio has a consensus target price of $12.19, suggesting a potential upside of 311.74%. Given Curis’ higher probable upside, research analysts plainly believe Curis is more favorable than ImmunityBio.
Summary
Curis beats ImmunityBio on 7 of the 13 factors compared between the two stocks.
About Curis
Curis, Inc., a biotechnology company, engages in the discovery and development of drug candidates for the treatment of human cancers in the United States. Its clinical stage drug candidates include Emavusertib, an oral small molecule IRAK4 kinase inhibitor, which is in a Phase 1/2 open-label, single arm expansion trial in patients with relapsed or refractory, or R/R, AML and high-risk myelodysplastic syndromes. The company’s pipeline also includes Fimepinostat, an oral dual inhibitor of HDAC and PI3K enzymes for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma; CA-170, an oral, small molecule antagonist designated as CA-170 that selectively targets PD-L1 and VISTA; and CA-327, an oral, small molecule, TIM3/PD-L1, which is a molecule antagonist of PD-L1 and TIM3. It has collaboration agreement with Genentech Inc., or Genentech and F. Hoffmann-La Roche Ltd, or Roche, for the commercialization of Erivedge, an orally-administered small molecule hedgehog signaling pathway antagonist for the treatment of advanced basal cell carcinoma, or BCC; Aurigene Discovery Technologies Limited for the discovery, development, and commercialization of small molecule compounds in the areas of immuno-oncology and precision oncology; and also licensed four programs under the Aurigene collaboration, including emavusertib. Curis, Inc. was incorporated in 2000 and is headquartered in Lexington, Massachusetts.
About ImmunityBio
ImmunityBio, Inc., a clinical-stage biotechnology company, engages in developing therapies and vaccines that bolster the natural immune system to defeat cancers and infectious diseases. Its platforms for the development of biologic product candidates include antibody-cytokine fusion proteins; DNA, RNA, and recombinant protein vaccines; and cell therapies. The company's platforms have generated therapeutic agents that are currently being or planned to be studied in clinical trials across various indications in liquid and solid tumors, including bladder, lung and colorectal cancers, and glioblastoma multiforme. Its lead biologic product candidate is Anktiva, an FDA-approved immunotherapy in combination with bacillus calmette-guérin (BCG) for the treatment of adult patients with BCG unresponsive non-muscle invasive bladder cancer with carcinoma in situ, with or without papillary tumors. The company has collaboration agreements with National Cancer Institute. It also has license agreements with 3M Innovative Properties Company; Access to Advanced Health Institute; LadRx Corporation; Sanford Health; Shenzhen Beike Biotechnology Co. Ltd.; Viracta Therapeutics, Inc.; and GlobeImmune, Inc. The company is based in San Diego, California.
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